Join our clinical research study evaluating whether directly targeting the APOL1 pathway can reduce protein in the urine and potentially slow or prevent kidney function decline.
Answer a few simple questions to see if you qualify for the study.
Are you between 18 and 65 years old?
Your information is secure and will only be used to determine study eligibility.
Taking part in this study may provide you with an opportunity to:
Have in-depth, long-term monitoring of your health. This includes access to specialist medical tests that would not be part of standard care outside of a clinical study.
Receive long-term nutrition and physical activity advice to support you in adopting healthier lifestyle choices.
Gain in-depth understanding of your condition.
Be a partner in this quest to help improve understanding of APOL1-mediated kidney disease.
Potentially help other people with APOL1-mediated kidney disease in the future.
This study evaluates whether a new medication (MZE829) can help reduce protein in the urine and protect kidney function in people with kidney disease related to the APOL1 gene.
Chronic kidney disease related to APOL1 gene variants disproportionately affects people of African ancestry. When these gene variants are present, they can cause progressive kidney damage characterized by protein leakage into the urine. Currently, there are no treatments that target the underlying genetic cause. This study tests whether directly targeting the APOL1 pathway can reduce protein in the urine and potentially slow or prevent kidney function decline.
The study lasts approximately 16 weeks total: 12 weeks taking the study medication, followed by a 4-week follow-up period.
The study is being conducted at Access Research Institute, located at 11373 Cortez Blvd Building C, Suite 200, Brooksville, FL 34613.

Dr. Lyle Breeding, MD, is a Board Certified General and Vascular Surgeon affiliated with HCA Florida Oak Hill Hospital and Suncoast General & Vascular Surgery. He earned his medical degree from the University of Kentucky and completed his General Surgery residency at George Washington Medical Center and the University of Kentucky. Dr. Breeding further specialized through a Vascular Surgery fellowship at Robert Wood Johnson University Hospital. With over two decades of experience, he specializes in a wide range of surgical procedures including minimally invasive and robotic surgery.
General & Vascular Surgery
Specializing in General and Vascular Procedures
Clinical Experience
"As a doctor, I see how challenging conditions like APOL1-mediated kidney disease can be. This study is a way for us to explore potential options that may help people feel better and live healthier lives. Every person who joins helps us move one step closer to better care in the future."
Participating in our study offers several potential advantages for patients with kidney disease related to the APOL1 gene.
Participants may receive access to innovative treatments that are not widely available in standard clinical practice.
Our specialized team of doctors, nurses, and specialists provide comprehensive care throughout the study.
Study-related treatments, evaluations, and follow-up visits are provided at no cost to eligible participants.
By participating, you help advance medical knowledge and potentially improve future treatments for this condition.
Ready to join our clinical study? It's simple. Just follow these easy steps.
Schedule your first chat with our friendly team. We'll talk about your health and see if this study is a good fit for you.
We'll go over your health background, current care, and understand your condition better.
We'll walk you through everything about the study – the potential benefits and risks, what to expect, and answer all your questions.
Next, we'll do a quick check-up to make sure the study is right for your specific needs.
If you feel ready to move forward, you'll review and sign the informed consent form.
This important paper explains everything: what happens in the study, the timeline, and your rights as a participant.
You'll get a personalized treatment plan made just for you, along with a clear schedule for your participation.
Embark on your study journey and begin your first treatment session!
Find answers to common questions about our clinical research study.
A clinical trial is a research study that evaluates new medical treatments, interventions, or devices to determine if they're safe and effective for humans. These studies follow strict scientific standards and regulatory guidelines to protect participants' safety and rights. By participating in our clinical trial, you're helping to advance medical knowledge and potentially improve future treatments for this disease.
Have more questions about the study?
Call Our Friendly TeamFind out if your a good fit for the study. Our team will contact you within 24 hours.

Limited Enrollment Period
We can only accept a limited number of participants for this study.
No-Cost Evaluation
Your consultation and all study-related care is provided at no cost to you.
No Obligation
The consultation is informational only - you decide if the study is right for you.
Complete this quick form to see if you qualify
Are you between 18 and 65 years old?
Your information is secure and will never be shared with third parties
11373 Cortez Blvd Building C, Suite 200
Brooksville, FL 34613
Monday-Friday: 9am-5pm
Free parking available
Wheelchair accessible